(4-氯-3-甲氧基苯基)甲醇合成路线 （共 16 条）
参考文献
Portola Pharmaceuticals, Inc.
Patent: US6906063 B2, 2005 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; dichloromethane T=0 - 20°C; 2: With water; sodium sulfate in tetrahydrofuran; dichloromethane
参考文献
ChemoCentryx, Inc.
Patent: US2007/88036 A1, 2007 ;
Location in patent: Page/Page column 25 ;
US 20070088036 A1
反应条件
sodium tetrahydroborate in ethanol 2 h;
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
反应条件
1: 58 percent / KMnO4 / 16 h / Heating 2: 94 percent / BH3 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Akita; Matsukura; Oishi
Tetrahedron Letters, 1986 , vol. 27, # 45 p. 5397 - 5400
反应条件
in tetrahydrofuran; water
参考文献
Sterling Winthrop Inc.
Patent: US5554620 A1, 1996 ;
反应条件
1: 80 percent / K2CO3 / acetone 2: 92 percent / KMnO4 / pyridine; H2O / 1.) 50 deg C, 24 h, 2.) RT, 13 h 3: 82 percent / LiAlH4 / diethyl ether; dioxane View Scheme
参考文献
Popovsky; Stepanov; Grigorieva
Russian Chemical Bulletin, 2012 , vol. 61, # 8 p. 1616 - 1621
Izv. Akad. Nauk, Ser. Khim., 2012 , # 8 p. 1599 - 1604
反应条件
1: 66 percent / K2CO3 / acetone / 1 h / Heating 2: 86 percent / sodium borohydride / ethanol / 2 h View Scheme
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
反应条件
1: SnCl2, aq. HCl 2: (i) aq. NaNO2, aq. HCl, (ii) /BRN= 1697325/, CuSO4, Na2SO3, NaOAc 3: HCHO, MeOH, aq. KOH View Scheme
参考文献
Munavalli,S. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3311 - 3318
反应条件
1: (i) aq. NaNO2, aq. HCl, (ii) /BRN= 1697325/, CuSO4, Na2SO3, NaOAc 2: HCHO, MeOH, aq. KOH View Scheme
参考文献
Munavalli,S. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3311 - 3318
反应条件
1: (i) NaNO2, aq. HCl, (ii) CuCl 2: SnCl2, aq. HCl 3: (i) aq. NaNO2, aq. HCl, (ii) /BRN= 1697325/, CuSO4, Na2SO3, NaOAc 4: HCHO, MeOH, aq. KOH View Scheme
参考文献
Munavalli,S. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3311 - 3318
