2-甲基-2-丙基[(1R)-2-氧代-1-苯基乙基]氨基甲酸酯合成路线 （共 12 条）
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=20°C; 2 h;
参考文献
Ramachandran, P. Veeraraghavan; Burghardt, Thomas E.; Reddy, M. Venkat Ram
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2329 - 2331
反应条件
Dess-Martin periodane
参考文献
Johnson, Erik P.; Hubieki, M. Patricia; Combs, Andrew P.; Teleha, Christopher A.
Synthesis, 2011 , # 24 art. no. M87311SS, p. 4023 - 4026
反应条件
ammonium chloride; triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
1: With ozone in dichloromethane
T=-78°C; 3 h;
2: With dimethylsulfide in dichloromethane
T=-78 - 20°C; 1.5 h;
参考文献
Ramachandran, P. Veeraraghavan; Burghardt, Thomas E.; Reddy, M. Venkat Ram
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2329 - 2331
反应条件
1: 73 percent / LiAlH4
View Scheme
参考文献
Liang, Ningning; Srinivas, Pusuluri; Datta, Apurba
Tetrahedron Letters, 2005 , vol. 46, # 42 p. 7221 - 7223
反应条件
1: 73 percent / LiAlH4
View Scheme
参考文献
Liang, Ningning; Srinivas, Pusuluri; Datta, Apurba
Tetrahedron Letters, 2005 , vol. 46, # 42 p. 7221 - 7223
反应条件
1.1: diethyl ether; pentane / 4 h / -100 - -78 °C
1.2: aq. NaOH; aq. H2O2 / diethyl ether; pentane / 14 h / -78 - 20 °C
1.3: pyridine / CH2Cl2 / 1 h / 0 °C
2.1: 2.0 g / K2CO3 / methanol / 3 h / 20 °C
3.1: NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / -42 °C
3.2: tetrahydrofuran / 1 h / -42 - 20 °C
3.3: 89 percent / K2CO3 / xylene / 14 h / 150 °C
4.1: KOH / ethanol; H2O / 24 h / 20 °C
5.1: 1.1 g / diethyl ether / 3 h / 20 °C
6.1: O3 / CH2Cl2 / 3 h / -78 °C
6.2: Me2S / CH2Cl2 / 1.5 h / -78 - 20 °C
View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Burghardt, Thomas E.; Reddy, M. Venkat Ram
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2329 - 2331
反应条件
1.1: NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / -42 °C
1.2: tetrahydrofuran / 1 h / -42 - 20 °C
1.3: 89 percent / K2CO3 / xylene / 14 h / 150 °C
2.1: KOH / ethanol; H2O / 24 h / 20 °C
3.1: 1.1 g / diethyl ether / 3 h / 20 °C
4.1: O3 / CH2Cl2 / 3 h / -78 °C
4.2: Me2S / CH2Cl2 / 1.5 h / -78 - 20 °C
View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Burghardt, Thomas E.; Reddy, M. Venkat Ram
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2329 - 2331
反应条件
1.1: KOH / ethanol; H2O / 24 h / 20 °C
2.1: 1.1 g / diethyl ether / 3 h / 20 °C
3.1: O3 / CH2Cl2 / 3 h / -78 °C
3.2: Me2S / CH2Cl2 / 1.5 h / -78 - 20 °C
View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Burghardt, Thomas E.; Reddy, M. Venkat Ram
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2329 - 2331
反应条件
1: CH2Cl2
2: (COCl)2, DMSO
View Scheme
参考文献
Veeresa; Datta, Apurba
Tetrahedron Letters, 1998 , vol. 39, # 19 p. 3069 - 3070
