FeCl3·6H2O in dichloromethane T=55 - 60°C; Friedel-Crafts cyclization; 6 h; Inert atmosphere;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '969135', constants.ctx, '0')">methyl iodide</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4948473', constants.ctx, '0')">magnesium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />0.166667&nbsp;h;&nbsp;&nbsp;RefluxInert atmosphere;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '22460938', constants.ctx, '0')">methyl N-tosyl-2-(4-chlorobenzylamino)acetate</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />0.25&nbsp;h;&nbsp;&nbsp;Inert atmosphereHeating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: pyridine / benzene / 12 h / 20 &deg;C / Inert atmosphere<br />2.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere<br />2.2: 6 h / Inert atmosphere<br />3.1: magnesium / diethyl ether / 0.17 h / Reflux; Inert atmosphere<br />3.2: 0.25 h / Inert atmosphere; Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: pyridine / benzene / 12 h / 20 &deg;C / Inert atmosphere<br />2.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / Inert atmosphere<br />2.2: 6 h / Inert atmosphere<br />3.1: magnesium / diethyl ether / 0.17 h / Reflux; Inert atmosphere<br />3.2: 0.25 h / Inert atmosphere; Heating<br /> <br /> &nbsp;