1: ZnCl2 / CH2Cl2 / 60 h / 20 °C 2: 190 mg / aq. HF / acetonitrile / 7 h / 0 - 23 °C View Scheme

1: With zinc(II) chloride in dichloromethane T=23°C; Mukaiyama aldol-lactonization; 60 h; Inert atmosphere; 2: With hydrogen fluoride in acetonitrile T=0 - 23°C; Inert atmosphere; optical yield given as percent de;

1: ZnCl2 / CH2Cl2 / 60 h / 20 °C 2: 190 mg / aq. HF / acetonitrile / 7 h / 0 - 23 °C 3: 84 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C View Scheme

1: ZnCl2 / CH2Cl2 / 60 h / 20 °C 2: 190 mg / aq. HF / acetonitrile / 7 h / 0 - 23 °C View Scheme

1: With zinc(II) chloride in dichloromethane T=23°C; Mukaiyama aldol-lactonization; 60 h; Inert atmosphere; 2: With hydrogen fluoride in acetonitrile T=0 - 23°C; Inert atmosphere; optical yield given as percent de;