反应条件
1: 1) N,N'-carbonyldiimidazole / 1) tetrahydrofuran, 30 min, 2) tetrahydrofuran, dimethyl sulfoxide, 4h, room temp. 2: 97 percent / H2 / RuBr2<(R)-binap> / ethanol / 145 h / 20 °C / 76000.1 Torr 3: 96 percent / aq. potassium hydroxide / dioxane / 8 h / 0 °C 4: H2 / 5percent Rh-Al2O3 / ethanol / 16 h / 3040 - 3800 Torr 5: 96 percent / DEPC, triethylamine / tetrahydrofuran / 6 h / 0 °C 6: 4N HCl / dioxane / 0.5 h / Ambient temperature 7: 91 percent / DEPC, triethylamine / tetrahydrofuran / 6 h / 0 °C 8: 4N HCl / dioxane / 0.5 h / Ambient temperature 9: 71 percent / DEPC, triethylamine / tetrahydrofuran / 8 h / 0 °C View Scheme
参考文献
Nishi; Saito; Nagahori; Kataoka; Morisawa; Yabe; Sakurai; Higashida; Shoji; Matsushita; Iijima; Ohizumi; Koike
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 103 - 109