N-Boc-L-缬氨酸合成路线 （共 134 条）
反应条件
1: 80 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenztriazole
2: 1.) 4N HCl; 2.) N-methylmorpholine / 2.) 0.1M AcOH / 1.) dioxane, r.t., 30 min; 2.) 2-butanol, reflux, 3 h
View Scheme
参考文献
Suzuki; Sasaki; Endo; Mihara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 233 - 237
反应条件
1: N,N-dicyclohexylcarbodiimide / CH2Cl2
2: HCl / CH2Cl2 / 0 °C
3: 1.) aq. sodium bicarbonate / 1.) room temperature; 2.) reflux, methanol, 24 h
View Scheme
参考文献
Smith, Grant Gill; Evans, Robert C.; Baum, Rocky
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7327 - 7332
参考文献
Wang, De-Xin; Liang, Ming-Tao; Tian, Gui-Jie; Lin, Hao; Liu, Hong-Qiang
Tetrahedron Letters, 2002 , vol. 43, # 5 p. 865 - 867
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; water / methanol / 4 h / 20 °C
View Scheme
参考文献
Ruderisch, Alexander; Pfeiffer, Jens; Schurig, Volker
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2025 - 2030
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in dichloromethane
T=5°C;
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide
参考文献
Tobe; Morishima; Aoyagi; et al.
Agricultural and Biological Chemistry, 1982 , vol. 46, # 7 p. 1865 - 1872
反应条件
1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; water / methanol / 4 h / 20 °C
View Scheme
参考文献
Ruderisch, Alexander; Pfeiffer, Jens; Schurig, Volker
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2025 - 2030
反应条件
1: t-Boc-L-valine With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=-10°C; 0.0833333 h;
2: L-Tyr-OBn With 4-methyl-morpholine; benzotriazol-1-ol in tetrahydrofuran; dichloromethane
T=20°C; 3 h;
参考文献
Reid, Robert C.; Kelso, Michael J.; Scanlon, Martin J.; Fairlie, David P.
Journal of the American Chemical Society, 2002 , vol. 124, # 20 p. 5673 - 5683
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide
1) CHCl3, 0-5 deg C, 15 min, 2) CHCl3, 6 h; Yield given. Multistep reaction;
参考文献
Abiko; Onodera; Sekino
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2507 - 2511
反应条件
1: DCC, HOBt, Et3N
2: TFA
3: DCC, HOBt, Et3N
4: TFA
5: DCC, HOBt, Et3N
6: H2 / Pd-C
View Scheme
参考文献
Rich, Daniel H.; Moon, Byung Jo; Boparai, Amrit S.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2288 - 2290
