N-Boc-L-缬氨酸合成路线 （共 134 条）
反应条件
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C 1.2: 24 h 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 5 h / 0 °C 3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C View Scheme
参考文献
Arjmand, Farukh; Jamsheera; Mohapatra
Journal of Photochemistry and Photobiology B: Biology, 2013 , vol. 121, p. 75 - 85
反应条件
1: 1.) Et3N, EtOCOCl, 2.) NaBH4 / 1.) THF, 0 deg C, 0.25 h, 2.) H2O, 0 deg C, 0.5 h, room temperature, 2 h 2: Et3N, DMAP / CH2Cl2 / Ambient temperature 3: dimethylformamide / 24 h / Ambient temperature 4: 6 M HCl / 12 h / Heating 5: aq. NaOH / 1.) 0 deg C, 0.5 h, 2.) room temperature, 2 h View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C / Cooling with ice 2.1: water; sodium hydroxide / methanol / 10 h 2.2: pH 2 - 3 3.1: formic acid / 8 h View Scheme
参考文献
Adhikari, Bimalendu; Banerjee, Arindam
Chemistry - A European Journal, 2010 , vol. 16, # 46 p. 13698 - 13705
反应条件
trifluoroacetic acid in methanol; dichloromethane; water
参考文献
THE UPJOHN COMPANY
Patent: EP146348 B1, 1991 ;
反应条件
1: 1.95 g / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH2Cl2 / 18 h / 20 °C 2: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 3: 2.6 g / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / CH2Cl2 / 18 h / 20 °C 4: trifluoroacetic acid / CH2Cl2 / 1 h / 20 °C 5: 411 mg / Et3N; 1-hydroxybenzotriazole hydrate; water soluble carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C 6: 96 percent / H2 / 10 percent Pd/C / dimethylformamide / 18 h / 20 °C 7: 6N HCl / 18 h / 105 °C View Scheme
参考文献
Momose, Isao; Sekizawa, Ryuichi; Hirosawa, Sehei; Ikeda, Daishiro; Naganawa, Hiroshi; Inuma, Hironobu; Takeuchi, Tomio
Journal of Antibiotics, 2001 , vol. 54, # 12 p. 1004 - 1012
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in pyridine; dichloromethane T=0 - 20°C; 50 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 44, # 6 p. 2339 - 2346
反应条件
1: DCC / dimethylformamide / 1 h / 0 °C 2: DMAP / dimethylformamide / 24 h / 20 °C View Scheme
参考文献
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, , vol. 59, # 9 p. 2033 - 2039
反应条件
4-(N,N-dimethlyamino)pyridine in DCM T=20°C;
参考文献
Tian Jin Hemay Bio-Tech Co., Ltd.
Patent: EP1867649 A1, 2007 ;
Location in patent: Page/Page column 10 ;
反应条件
24 h; Product distribution;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 23 p. 1225 - 1227
反应条件
1: t-Boc-L-valine With 4-methyl-morpholine; isobutyl chloroformate in ethyl acetate T=0°C; Inert atmosphere; 2: O,N-dimethyl-hydroxylamine hydrochloride in ethyl acetate T=0 - 20°C; 48.25 h; Inert atmosphere;
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
