N-Boc-L-缬氨酸合成路线 （共 134 条）
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in pyridine; dichloromethane Condensation;
参考文献
Hulme, Christopher; Ma, Liang; Romano, Joseph; Morrissette, Matthew
Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7925 - 7928
反应条件
silver(l) oxide in N,N-dimethyl-formamide T=45°C; 20 h;
参考文献
Lan, Hong-Qiao; Ye, Jian-Liang; Wang, Ai-E; Ruan, Yuan-Ping; Huang, Pei-Qiang
Chemistry - A European Journal, 2011 , vol. 17, # 3 p. 958 - 968
反应条件
1: 91 percent / NaH / tetrahydrofuran / 24 h / Ambient temperature 2: 98 percent / diethyl ether / 0 °C View Scheme
参考文献
Andrus, Merritt B.; Li, Wenke; Keyes, Robert F.
Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5542 - 5549
反应条件
1: HOBT, dicyclohexylcarbodiimide 2: HF, anisole-thioanisole-o-cresol / 0.5 h / ice-bath View Scheme
参考文献
Becu, Fr.; Becu, Chr.; Anteunis, M. J. O.
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 1 p. 15 - 23
反应条件
1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C 2.1: triethylamine / dichloromethane / 0.5 h 2.2: 18 h / 20 °C 3.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C 4.1: dichloromethane / 84 h / 20 °C View Scheme
参考文献
Chen, Jianxie; Corbin, Scott P.; Holman, Nicholas J.
Organic Process Research and Development, 2005 , vol. 9, # 2 p. 185 - 187
反应条件
1: With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate in tetrahydrofuran T=-10°C; 0.25 h; 2: With sodium tetrahydroborate; water in tetrahydrofuran T=-10°C; 0.0833333 h; Inert atmosphere;
参考文献
Rotstein, Benjamin H.; Yudin, Andrei K.
Synthesis (Germany), 2012 , vol. 44, # 18 p. 2851 - 2858
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine in N,N-dimethyl-formamide T=4°C;
参考文献
Valverde, Ibai E.; Huxol, Elena; Mindt, Thomas L.
Journal of Labelled Compounds and Radiopharmaceuticals, 2014 , vol. 57, # 4 p. 275 - 278
反应条件
1: With triethylamine T=0°C; 2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine
参考文献
Falkiewicz; Wisniowski; Kolodziejczyk; Wisniewski
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1393 - 1397
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
triethylamine in dichloromethane
参考文献
Accuthera, Inc.
Patent: US2009/156509 A1, 2009 ;
US 20090156509 A1
