1.1: tetrakis(triphenylphosphine) palladium(0); N,N'-dimethyl-barbituric acid / dichloromethane / 6 h / 50 °C 2.1: potassium carbonate / dichloromethane; water / 2.5 h / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux 4.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C 4.2: 1 h / 50 °C View Scheme

1.1: tetrakis(triphenylphosphine) palladium(0); N,N'-dimethyl-barbituric acid / dichloromethane / 6 h / 50 °C 2.1: potassium carbonate / dichloromethane; water / 2.5 h / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux 4.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C 4.2: 1 h / 50 °C View Scheme

1: tetrakis(triphenylphosphine) palladium(0); N,N'-dimethyl-barbituric acid / dichloromethane / 6 h / 50 °C 2: potassium carbonate / dichloromethane; water / 2.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux View Scheme