1H-螺[茚-1,4-哌啶]-1-羧酸叔丁酯合成路线 (共 14 条)
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=0°C;
参考文献
Chen, Xiaoqi; Mihalic, Jeff; Fan, Pingchen; Liang, Lingming; Lindstrom, Michelle; Wong, Sylvia; Ye, Qiuping; Fu, Ying; Jaen, Juan; Chen, Jin-Long; Dai, Kang; Li, Leping
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 363 - 366
参考文献
Merck Sharp and Dohme Limited
Patent: US5219860 A1, 1993 ;
US 5219860 A
反应条件
in tetrahydrofuran; hexane; dichloromethane; lithium hexamethyldisilazane
参考文献
US5693643 A1, ;
US 5693643 A
反应条件
in tetrahydrofuran; hexane; dichloromethane; lithium hexamethyldisilazane
参考文献
US5091387 A1, ;
US 5091387 A
反应条件
1: 88 percent / triethylamine / CH2Cl2 2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 11 p. 2033 - 2039
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 0.166667 h; 2: With sodium hydrogencarbonate in chloroform; water
参考文献
KOWA COMPANY, LTD.
Patent: US2010/22572 A1, 2010 ;
Location in patent: Page/Page column 13-14 ;
US 20100022572 A1
反应条件
1: 1.) 9-NBN, 2.) PCC 2: TFA / CH2Cl2 View Scheme
参考文献
Tata, James R.; Nargund, Ravi P.; Murphy, Marcia M.; Johnston, David B. R.; Patchett, Arthur A.; Cheng, Kang; Wei, Liente; Chan, Wanda W.-S.; Butler, Bridget; Jacks, Thomas M.; Hickey, Gerard; Smith, Roy
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 663 - 668
反应条件
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide
参考文献
AMIRA PHARMACEUTICALS, INC
Patent: WO2009/61681 A2, 2009 ;
Location in patent: Page/Page column 65 ;
WO 2009/061681 A2
反应条件
sodium hydroxide; borane; dihydrogen peroxide in tetrahydrofuran
参考文献
Tata, James R.; Nargund, Ravi P.; Murphy, Marcia M.; Johnston, David B. R.; Patchett, Arthur A.; Cheng, Kang; Wei, Liente; Chan, Wanda W.-S.; Butler, Bridget; Jacks, Thomas M.; Hickey, Gerard; Smith, Roy
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 663 - 668
反应条件
hydrogenchloride in ethanol; palladium; ethyl acetate
参考文献
Merck Sharp and Dohme Limited
Patent: US5219860 A1, 1993 ;
US 5219860 A