1H-螺[茚-1,4-哌啶]-1-羧酸叔丁酯合成路线 （共 14 条）
反应条件
1: 99 percent / HCl(g) / ethyl acetate / 0.5 h / 0 °C 2: 43 percent / H2 / Pd/C / ethanol / 1 h / 2585.7 Torr View Scheme
参考文献
Chambers; Baker; Billington; Knight; Middlemiss; Wong
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2033 - 2039
反应条件
hydrogenchloride in ethyl acetate T=0°C; 0.5 h;
参考文献
Chambers; Baker; Billington; Knight; Middlemiss; Wong
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2033 - 2039
反应条件
1: HCl (g) / ethyl acetate / 0.5 h / 12 °C 2: triethylamine / CH2Cl2 / 1 h / Ambient temperature 3: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 10 min 4: LiOH*H2O / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Evans, Ben E.; Leighton, James L.; Rittle, Kenneth E.; Gilbert, Kevin F.; Lundell, George F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3919 - 3927
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/38459 A2, 2007 ;
Location in patent: Page/Page column 72 ;
