2-甲基-5-苯基-噻唑-4-羧酸合成路线 （共 5 条）
反应条件
potassium hydroxide in methanol; water 2 h; Heating;
参考文献
Mamedov; Gubaidullin; Nurkhametova; Litvinov; Levin
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 4 p. 534 - 542
反应条件
25 Pd/C; hydrogen in ethyl acetate T=20°C; P=760.051 Torr;
参考文献
Sanz-Cervera, Juan F.; Blasco, Rauel; Piera, Julio; Cynamon, Michael; Ibanez, Ignacio; Murguia, Marcelo; Fustero, Santos
Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 8988 - 8996
反应条件
1: in ethanol 0.5 h; Heating / reflux; 2: With ammonia in ethanol; water pH=10; 3: With hydrogenchloride in ethanol; water T=45°C; pH=3;
参考文献
WO2008/150364 A1, ;
Page/Page column 32-33 ;
WO 2008/150364 A1
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / -60 - 20 °C 2.1: acetonitrile / 5 h / Molecular sieve 2.2: 6 h / 50 °C 3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h 3.2: pH 3 - 4 / Cooling with ice View Scheme
反应条件
1.1: acetonitrile / 5 h / Molecular sieve 1.2: 6 h / 50 °C 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h 2.2: pH 3 - 4 / Cooling with ice View Scheme
