1.1: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C 2.1: HOBt; BOP; DIPEA / dimethylformamide / 0.17 h / 0 °C 2.2: Et3N / dimethylformamide / 0 - 20 °C 3.1: HCl / dioxane / 0 - 20 °C 4.1: DIPEA / dimethylformamide / 0 - 20 °C View Scheme

hydrogen; palladium on activated charcoal in ethanol 24 h;

1: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h 2: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature 3: H2 / 10percent Pd/C / ethanol / 16 h 4: 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 16 h / Ambient temperature View Scheme

1: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h 2: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature View Scheme