11-氯-二苯并[b,f][1,4]硫氮杂卓合成路线 （共 18 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=106°C; 6 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2007/62339 A2, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
phosphorus pentachloride; nitrogen in dichloromethane
反应条件
trichlorophosphate 5 - 6 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2006/27789 A1, ;
Page/Page column 9; 14; 15 ;
反应条件
1: polyphosphoric acid / Heating 2: N,N-dimethyl-aniline; trichlorophosphate / 105 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 50, # 9 p. 1196 - 1201
反应条件
1: hydrogen / methanol / 4137.29 Torr 2: sodium carbonate 3: polyphosphoric acid / Heating 4: N,N-dimethyl-aniline; trichlorophosphate / 105 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 50, # 9 p. 1196 - 1201
反应条件
1: sodium carbonate 2: polyphosphoric acid / Heating 3: N,N-dimethyl-aniline; trichlorophosphate / 105 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 50, # 9 p. 1196 - 1201
反应条件
1: potassium hydroxide / water; isopropyl alcohol 2: ethyl acetate 3: triethylamine; benzotriazol-1-ol / dichloromethane 4: trichlorophosphate View Scheme
反应条件
1: ethyl acetate 2: triethylamine; benzotriazol-1-ol / dichloromethane 3: trichlorophosphate View Scheme
反应条件
1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C 5: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C 5: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
