11-氯-二苯并[b,f][1,4]硫氮杂卓合成路线 （共 18 条）
反应条件
hydrogenchloride in ethanol; toluene
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP282236 B1, 1991 ;
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2006/135544 A1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
in toluene T=110 - 120°C; 8 h; Product distribution / selectivity;
参考文献
SANDOZ AG
Patent: WO2007/20011 A1, 2007 ;
Location in patent: Page/Page column 14; 16 ;
反应条件
potassium carbonate in sulfolane T=95 - 100°C; 4 h;
参考文献
ALEMBIC LIMITED; DEO, Keshav; PRASAD, Ashok; PANCHASARA, Dinesh
Patent: WO2010/29458 A2, 2010 ;
Location in patent: Page/Page column 7-9 ;
反应条件
in xylene T=170°C; 12 - 18 h;
参考文献
CONCERT PHARMACEUTICALS INC.
Patent: WO2008/66620 A2, 2008 ;
Location in patent: Page/Page column 23-24 ;
反应条件
hydrogenchloride in isopropyl alcohol; toluene
参考文献
Niphade, Navnath C.; Mali, Anil C.; Pandit, Bhushan S.; Jagtap, Kunal M.; Jadhav, Sanjay A.; Jachak, Madhukar N.; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 792 - 797
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2006/135544 A1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
in toluene
4 h; Heating;
参考文献
Bharathi; Prabahar; Prasad; Srinivasa Rao; Trinadhachary; Handa; Dandala, Ramesh; Naidu
Pharmazie, 2008 , vol. 63, # 1 p. 14 - 19
