反应条件
1: 80 percent / 10percent NaOH / 2-methoxy-ethanol / 18 h / Ambient temperature
2: 1.) Et3N, isobutyl chloroformate / 1.) DMSO, 1.5 h, 2.) DMSO, RT, 22 h
3: 73 percent / NaOH / 2-methoxy-ethanol / 4 h / Ambient temperature
View Scheme
参考文献
DeGraw; Christie; Colwell; Sirotnak
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 320 - 324
