(2S)-2-[[4-(1,3-二氨基-7,8,9,10-四氢嘧啶并[6,5-c]异喹啉-8-基)苯甲酰基]氨基]戊烷二酸合成路线 （共 11 条）
反应条件
1: 56 percent / BH3*THF / tetrahydrofuran / 16 h / Ambient temperature
2: 61 percent / DDQ / acetic acid / 18 h / Ambient temperature
3: 80 percent / 10percent NaOH / 2-methoxy-ethanol / 18 h / Ambient temperature
4: 1.) Et3N, isobutyl chloroformate / 1.) DMSO, 1.5 h, 2.) DMSO, RT, 22 h
5: 73 percent / NaOH / 2-methoxy-ethanol / 4 h / Ambient temperature
View Scheme
参考文献
DeGraw; Christie; Colwell; Sirotnak
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 320 - 324
