(S)-1-叔丁氧羰基-2-甲基吡咯烷合成路线 （共 13 条）
反应条件
1: With lithium triethylborohydride in tetrahydrofuran T=0 - 20°C; 2: With water in tetrahydrofuran; ethyl acetate
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/19833 A1, 2006 ;
Location in patent: Page/Page column 61 ;
WO 2006/019833 A1
反应条件
lithium triethylborohydride in tetrahydrofuran T=0°C; 15 h;
参考文献
Ku, Yi-Yin; Cowart, Marlon D.; Sharma, Padam N.
Patent: US2004/260100 A1, 2004 ;
Location in patent: Page 8 ;
US 20040260100 A1
反应条件
1: N-Boc-pyrrolidine With sec.-butyllithium; (-)-sparteine in diethyl ether; cyclohexane T=-78°C; 5.5 h; 2: dimethyl sulfate in diethyl ether; cyclohexane T=-78°C; Further stages.;
参考文献
Bertini Gross; Beak
Journal of the American Chemical Society, 2001 , vol. 123, # 2 p. 315 - 321
反应条件
1: N-(tert-butoxycarbonyl)-2-trimethylstannylpyrrolidine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: dimethyl sulfate in tetrahydrofuran; hexane T=-78°C; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 2 p. 315 - 321
参考文献
Tetrahedron, , vol. 50, # 20 p. 6089 - 6096
反应条件
in tert-butyl methyl ether; cyclohexane
参考文献
WO2008/73825 A1, ;
Page/Page column 292-294 ;
WO 2008/073825 A1
反应条件
1: N-Boc-pyrrolidine With sec.-butyllithium; (+)-sparteine surrogate in diethyl ether; hexane T=-30°C; 0.0333333 h; 2: dimethyl sulfate in diethyl ether; hexane Overall yield = 55 percent; Overall yield = 102 mg; enantioselective reaction;
参考文献
Organic Letters, , vol. 15, # 21 p. 5424 - 5427
反应条件
1: 95 percent / triethylamine / CH2Cl2 / -3 °C 2: 100 percent / NaH / tetrahydrofuran / Heating 3: 100 percent / Raney Ni / ethanol; H2O / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 8 p. 1223 - 1226
反应条件
1: 99 percent / BH3*THF / tetrahydrofuran / 1.) 0 deg C, 1 h; 2.) RT; 3.) 0 deg C, 1 h 2: 95 percent / triethylamine / CH2Cl2 / -3 °C 3: 100 percent / NaH / tetrahydrofuran / Heating 4: 100 percent / Raney Ni / ethanol; H2O / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 8 p. 1223 - 1226
反应条件
1: dichloromethane / 0 - 20 °C / |Ionic liquid 2: (+)-sparteine surrogate; sec.-butyllithium / diethyl ether; hexane / 0.03 h / -30 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 21 p. 5424 - 5427
