4-甲基-1,3-噻唑-2-甲醛合成路线 （共 14 条）
参考文献
Kondo; Nagasawa
Yakugaku Zasshi, 1937 , vol. 57, p. 909,913; dtsch. Ref. S. 249, 252
Chem.Abstr., 1938 , p. 1699
反应条件
1: With sodium tetrahydroborate in methanol T=0°C; 0.75 h; 2: With water; ammonium chloride Product distribution / selectivity;
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
Location in patent: Page/Page column 82 ;
WO 2012/054510 A1
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane
T=0 - 5°C; 1 h; Inert atmosphere;
2: 4-methyl-2-thiazolylcarboxaldehyde in tetrahydrofuran; hexane
T=0 - 20°C;
参考文献
UCB PHARMA, S.A.; ATES, Ali; MONTEL, Florian; VALADE, Anne; LORTHIOIR, Olivier
Patent: WO2013/53725 A1, 2013 ;
Location in patent: Page/Page column 52 ;
反应条件
1: reducing agent
2: chlorinating agent
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参考文献
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY; LAVOIE, Edmond J.; PARHI, Ajit; ZHANG, Yongzheng; PILCH, Daniel S.; KAUL, Malvika
Patent: WO2013/142712 A1, 2013 ;
