2-((乙氧基羰基)氨基)乙酸甲酯合成路线 （共 7 条）
反应条件
triethylamine in chloroform 24 h; Reflux;
参考文献
PURDUE RESEARCH FOUNDATION; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTENT OF HEALTH and HUMAN SERVICES
Patent: WO2009/140467 A1, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
1: With ozone T=-78°C; 2: With sodium hydroxide in methanol T=-78 - 20°C;
参考文献
Francavilla, Matteo; Gasperi, Tecla; Loreto, M. Antonietta; Tardella, Paolo A.; Bassetti, Mauro
Tetrahedron Letters, 2002 , vol. 43, # 44 p. 7913 - 7916
反应条件
CaO in dichloromethane T=20°C; 6 h;
参考文献
Fioravanti, Stefania; Pellacani, Lucio; Ramadori, Federico; Tardella, Paolo A.
Tetrahedron Letters, 2007 , vol. 48, # 44 p. 7821 - 7824
反应条件
potassium carbonate 12 h; Ambient temperature;
参考文献
Kanth; Periasamy
Synthetic Communications, 1995 , vol. 25, # 10 p. 1523 - 1530
反应条件
diethyl ether nicht rein erhalten;
参考文献
Geake; Nierenstein
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1914 , vol. 92, p. 151
反应条件
1: N-(ethoxycarbonyl)-α-amino methyl carboxylic ester With sodium hydride in benzene T=20°C; 16 h; Reflux; 2: acrylic acid methyl ester in benzene Michael condensation; 8 h; Reflux;
参考文献
PURDUE RESEARCH FOUNDATION; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTENT OF HEALTH and HUMAN SERVICES
Patent: WO2009/140467 A1, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
1: N-(ethoxycarbonyl)-α-amino methyl carboxylic ester With sodium hydride in benzene
T=20 - 100°C; Metallation; 12 h;
2: ethyl acrylate in benzene
Cyclization; 2 h; Heating;
参考文献
Yadav; Sarkar, Sanjita; Chandrasekhar
Tetrahedron, 1999 , vol. 55, # 17 p. 5449 - 5456
