2,3-二溴-5-氯吡啶合成路线 （共 14 条）
反应条件
magnesium sulfate in N-methyl-acetamide; hexane
参考文献
Pfizer Inc.
Patent: US5436344 A1, 1995 ;
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide T=80°C; 72 h;
参考文献
Quallich, George J.; Fox, Darrell E.; Friedmann, Robert C.; Murtiashaw, C. William
Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 761 - 764
反应条件
in N-methyl-acetamide; hexane
参考文献
Pfizer Inc.
Patent: US5068333 A1, 1991 ;
US 5068333 A
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=-5 - 60°C;
参考文献
Tetrahedron, , vol. 60, # 51 p. 11869 - 11874
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere 1.2: 120 °C 2.1: hydrogenchloride / water / Reflux View Scheme
参考文献
ASTRAZENECA AB
Patent: US2012/165347 A1, 2012 ;
US 20120165347 A1
反应条件
in anhydrous propionitrile T=150°C; 2.5 h; Microwave irradiation;
参考文献
ASTRAZENECA AB
Patent: US2010/125081 A1, 2010 ;
Location in patent: Page/Page column 18 ;
US 20100125081 A1
参考文献
WHITE, Ryan; ALLEN, Jennifer R.; EPSTEIN, Oleg; HONG, Fang-Tsao; HUA, Zihao; HUMAN, Jason Brooks; LOPEZ, Patricia; OLIVIERI, Philip R.; ROMERO, Karina; SCHENKEL, Laurie; STELLWAGEN, John; TAMAYO, Nuria A.; ZHENG, Xiao Mei
Patent: US2014/213581 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
chloro-trimethyl-silane; sodium iodide in various solvent(s) 0.75 h; Heating;
参考文献
Tetrahedron, , vol. 60, # 51 p. 11869 - 11874
反应条件
potassium carbonate; bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane; water T=50°C; RefluxInert atmosphere;
参考文献
US2012/165347 A1, ;
Page/Page column 32 ;
US 20120165347 A1
反应条件
1,3-bis-(diphenylphosphino)propane; nickel dichloride in tetrahydrofuran T=0°C; 0.0833333 h;
参考文献
Quallich, George J.; Fox, Darrell E.; Friedmann, Robert C.; Murtiashaw, C. William
Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 761 - 764
