2,3-二溴-5-氯吡啶合成路线 （共 14 条）
反应条件
1.1: isopropylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1 h / -40 °C 1.2: 0.5 h / -40 - 20 °C 2.1: sodium tetrahydroborate; methanol / 1 h / 5 - 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; CHEN, Frank; MOLINARO, Carmela; WUELFING, W. Peter; YASUDA, Nobuyoshi; YIN, Jianguo; ZHONG, Yong-Li; LYNCH, Joseph; ANDREANI, Teresa
Patent: WO2013/169348 A1, 2013 ;
反应条件
1: 2,3-dibromo-5-chloro-pyridine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-40°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-40 - 20°C; 0.5 h;
参考文献
MERCK SHARP and DOHME CORP.; CHEN, Frank; MOLINARO, Carmela; WUELFING, W. Peter; YASUDA, Nobuyoshi; YIN, Jianguo; ZHONG, Yong-Li; LYNCH, Joseph; ANDREANI, Teresa
Patent: WO2013/169348 A1, 2013 ;
Location in patent: Page/Page column 76 ;
反应条件
chloro-trimethyl-silane; sodium iodide in various solvent(s)
0.75 h; Heating;
参考文献
Cottet, Fabrice; Schlosser, Manfred
Tetrahedron, 2004 , vol. 60, # 51 p. 11869 - 11874
反应条件
1: 9.7 g / sodium iodide; chlorotrimethylsilane / various solvent(s) / 0.75 h / Heating
2: 69 percent / potassium fluoride; cuprous iodide; N-methylpyrrolidinone / Heating
View Scheme
参考文献
Cottet, Fabrice; Schlosser, Manfred
Tetrahedron, 2004 , vol. 60, # 51 p. 11869 - 11874
