2-(2-二甲胺乙基)-5-甲基-吡唑-3-基胺合成路线 （共 7 条）
反应条件
potassium hydroxide in water 3 h; Heating;
参考文献
Horne, Stephen; Rodrigo, Russell
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4520 - 4522
反应条件
potassium permanganate in water; acetone Oxidation; 3 h; Heating;
参考文献
Smith III, Amos B.; Wan, Zehong
Organic Letters, 1999 , vol. 1, # 9 p. 1491 - 1494
反应条件
[Rh(OH)(cycloocta-1,5-diene)]2; 1,3-bis-(diphenylphosphino)propane; water; sodium hydroxide in toluene T=110°C; 12 h; Inert atmosphere;
参考文献
Sun, Zhong-Ming; Zhang, Jing; Zhao, Pinjing
Organic Letters, 2010 , vol. 12, # 5 p. 992 - 995
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 1 h;
参考文献
US2008/119496 A1, ;
Page/Page column 34 ;
反应条件
sulfuric acid Esterification; 24 h; Heating;
参考文献
Smith III, Amos B.; Wan, Zehong
Organic Letters, 1999 , vol. 1, # 9 p. 1491 - 1494
反应条件
1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C 2: triphenylphosphine; carbon tetrabromide / dichloromethane / 2 h / 20 °C View Scheme
参考文献
MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
反应条件
1: sodium amide / tetrahydrofuran / 16 h / 50 °C
2: phosphorous pentoxide; phosphoric acid / 16 h / 110 °C
View Scheme
参考文献
Deiters, Emmanuel; Gumy, Frederic; Buenzli, Jean-Claude G.
European Journal of Inorganic Chemistry, 2010 , # 18 p. 2723 - 2734
