(5-氟-1-苯并噻吩-2-基)甲醇合成路线 （共 4 条）
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran T=-70 - -10°C; 2 h; 2: With methanol in tetrahydrofuran T=-70°C;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0829 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
反应条件
1: 53 percent / potassium carbonate / dimethylformamide / 20 h / 20 - 60 °C 2: 96 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 12, # 9 p. 2251 - 2273
反应条件
manganese(IV) oxide in dichloromethane T=52°C; 2 h;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0831 ;
