螺[茚-1,4’-哌啶]盐酸盐合成路线 （共 4 条）
反应条件
hydrogenchloride in ethyl acetate T=0°C; 0.5 h;
参考文献
Chambers; Baker; Billington; Knight; Middlemiss; Wong
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2033 - 2039
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 1 h;
参考文献
Chambers; Baker; Billington; Knight; Middlemiss; Wong
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2033 - 2039
反应条件
hydrogenchloride in ethanol; palladium; ethyl acetate
参考文献
Merck Sharp and Dohme Limited
Patent: US5219860 A1, 1993 ;
US 5219860 A
反应条件
1: triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 10 min 3: LiOH*H2O / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Evans, Ben E.; Leighton, James L.; Rittle, Kenneth E.; Gilbert, Kevin F.; Lundell, George F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3919 - 3927
