1-(2-羟基丙基)-3-甲氧基-2-甲基-6-(3-甲基丁-2-烯基)-9H-咔唑-4-醇合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
T=25°C; 0.75 h;
参考文献
Choi, Taylor A.; Czerwonka, Regina; Forke, Ronny; Jaeger, Anne; Knoell, Jan; Krahl, Micha P.; Krause, Tilo; Reddy, Kethiri R.; Franzblau, Scott G.; Knoelker, Hans-Joachim
Medicinal Chemistry Research, 2008 , vol. 17, # 2-7 p. 374 - 385
反应条件
1.1: 77 percent / HNO3; HOAc / 25 °C
2.1: 100 percent / H2 / Pd/C / methanol / 25 °C
3.1: air / acetonitrile / 168 h / 25 °C
3.2: NBS; Na2CO3 / acetonitrile / 25 °C
4.1: 88 percent / NBS; HBr / acetonitrile / 25 °C
5.1: Ni(CO)4 / benzene / 60 °C
5.2: 66 percent / benzene; dimethylformamide / 16 h / 65 °C
6.1: 92 percent / LiAlH4 / diethyl ether / 0.75 h / 25 °C
View Scheme
参考文献
Czerwonka, Regina; Reddy, Kethiri R.; Baum, Elke; Knoelker, Hans-Joachim
Chemical Communications, 2006 , # 7 p. 711 - 713
反应条件
1.1: 98 percent / Et3N / 48 h / Heating
2.1: n-BuLi; TMEDA / diethyl ether / 25 °C
2.2: 96 percent / diethyl ether / -78 - 25 °C
3.1: 100 percent / NBS / acetonitrile / 25 °C
4.1: 91 percent / t-BuLi / tetrahydrofuran / -78 °C
5.1: 100 percent / TBAF; H2O / tetrahydrofuran / 25 °C
6.1: 98 percent / Et3N; DMAP / CH2Cl2 / 25 °C
7.1: 77 percent / HNO3; HOAc / 25 °C
8.1: 100 percent / H2 / Pd/C / methanol / 25 °C
9.1: air / acetonitrile / 168 h / 25 °C
9.2: NBS; Na2CO3 / acetonitrile / 25 °C
10.1: 88 percent / NBS; HBr / acetonitrile / 25 °C
11.1: Ni(CO)4 / benzene / 60 °C
11.2: 66 percent / benzene; dimethylformamide / 16 h / 65 °C
12.1: 92 percent / LiAlH4 / diethyl ether / 0.75 h / 25 °C
View Scheme
参考文献
Czerwonka, Regina; Reddy, Kethiri R.; Baum, Elke; Knoelker, Hans-Joachim
Chemical Communications, 2006 , # 7 p. 711 - 713
