5-溴-6-甲基吡啶-2-甲醛合成路线 （共 4 条）
反应条件
diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere;
参考文献
ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Chery, A.; JONES, Todd, K.; NIPHAKIS, Micah, J.; CHANG, Jae, Won; LUM, Kenneth, M.; CRAVATT, Benjamin, F.
Patent: WO2013/103973 A1, 2013 ;
Location in patent: Paragraph 00386 ;
反应条件
1: 3-bromo-6-iodo-2-methylpyridine With isopropylmagnesium chloride in tetrahydrofuran; dichloromethane T=-20°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; dichloromethane T=-20 - 20°C;
参考文献
Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin
Patent: US2010/222345 A1, 2010 ;
Location in patent: Page/Page column 95 ;
反应条件
selenium(IV) oxide in 1,4-dioxane; water 1.5 h; Heating;
参考文献
Ban-Oganowska, Hanna; Talik, Tadeusz
Polish Journal of Chemistry, 1991 , vol. 65, # 2-3 p. 289 - 295
反应条件
1: 2.) HCl / 1.) 120 deg C, 3 h, 2.) a.) 60 deg C, 4 h, b.) RT, 24 h 2: 86 percent / selenium dioxide / dioxane; H2O / 1.5 h / Heating View Scheme
参考文献
Ban-Oganowska, Hanna; Talik, Tadeusz
Polish Journal of Chemistry, 1991 , vol. 65, # 2-3 p. 289 - 295
