咪唑并[1,5-a]吡啶-7-羧酸甲酯合成路线 （共 7 条）
反应条件
trichlorophosphate in 1,2-dichloro-ethane T=90°C; 1 h;
参考文献
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling
Patent: WO2013/127268 A1, 2013 ;
Location in patent: Page/Page column 71; 72 ;
参考文献
Rogers, Bruce N.; Piotrowski, David W.; Walker, Daniel Patrick; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Groppi JR., Vincent E.
Patent: US2003/236264 A1, 2003 ;
Location in patent: Page 51 ;
反应条件
1: chloroform / 50 °C / |Inert atmosphere 2: hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr 3: 2 h / 100 °C 4: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 90 °C View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling
Patent: WO2013/127268 A1, 2013 ;
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane 2: chloroform / 50 °C / |Inert atmosphere 3: hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr 4: 2 h / 100 °C 5: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 90 °C View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling
Patent: WO2013/127268 A1, 2013 ;
反应条件
1: hydrogen / methanol / 0.5 h / 20 °C / 760.05 Torr 2: 2 h / 100 °C 3: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 90 °C View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling
Patent: WO2013/127268 A1, 2013 ;
反应条件
1: 2 h / 100 °C 2: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 90 °C View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling
Patent: WO2013/127268 A1, 2013 ;
反应条件
hydrogenchloride; water 3 h; Heating / reflux;
参考文献
Rogers, Bruce N.; Piotrowski, David W.; Walker, Daniel Patrick; Jacobsen, Eric Jon; Acker, Brad A.; Wishka, Donn G.; Groppi JR., Vincent E.
Patent: US2003/236264 A1, 2003 ;
Location in patent: Page 52 ;
