1: H2 / Pd/C / ethanol / 24 h / 20 °C / 2585.7 Torr 3: LiOH, H2O2 / tetrahydrofuran; H2O / 0.5 h / 0 °C 4: TFA / CH2Cl2 / 30 h / 20 °C 5: HOBT, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl / CH2Cl2 / 3 h / 0 to 20 deg c 6: H2 / Pd/C / ethyl acetate / 2 h / 20 °C 7: Et3N / tetrahydrofuran / 3 h / 0 °C 8: TBAF / tetrahydrofuran / 3 h / 0 °C 9: Et3N, DMAP / CH2Cl2 / 3 h / 20 °C 10: H2 / Pd/C / methanol; ethyl acetate 11: 66 percent / HOBT, 1-(3-dimethylaminopropyl)-ethylcarbodiimide*HCl / CH2Cl2; dimethylformamide / 10 h / 0 to 20 deg C 12: 54 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C View Scheme