trifluoroacetic acid in dichloromethane T=20°C; 20.5 h;

1.1: dichloromethane / 20 °C 1.2: 20.08 h / 14 - 30 °C 2.1: sodium hydroxide; water / dichloromethane / Cooling with ice View Scheme

1: 98 percent / I2, Ph3P, imidazole / CH2Cl2 / 3 h / Ambient temperature 2: 1.) NaH / 1.) THF, 2.) THF, RT, 1 h 3: 96 percent / aq. KOH / ethanol / 7 h / Heating 4: 67 percent / bis-(2-hydroxy-ethyl) ether / 3 h 5: 70 percent / polyphosphoric acid / diethyl ether / 2 h / 120 °C View Scheme

1: 95 percent / Ph3PBr2 / acetonitrile / Heating 2: 74 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / various solvent(s) View Scheme

暂无反应条件数据

1: 90 percent / SOCl2, pyridine / diethyl ether 2: 60 percent / dimethylsulfoxide / 3 h / Heating 3: 70 percent / aq. KOH / 5 h / Heating View Scheme

1.1: trifluoroacetic acid / dichloromethane / 20.5 h / 20 °C 2.1: triethylamine / dichloromethane / 5 h / 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 3.2: -78 - 20 °C / Inert atmosphere 4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C 5.1: triethylamine / tetrahydrofuran / 20 h / 65 °C 6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C 6.2: 0.5 h / -78 °C 6.3: 2 h / -78 - 0 °C 7.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C 8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C 9.1: N,N-diethylaniline / ethanol; hexane / Resolution of racemate View Scheme

boron trifluoride diethyl etherate in dichloromethane T=-78 - 20°C;

PPh3.Br2 in acetonitrile Bromination; Heating;

pyridine in acetonitrile 2 h;