potassium hydroxide in methanol; water T=80°C; 3 h;

1: 85 percent / KOH / methanol; H2O / 3 h / 80 °C 2: 0.86 percent / NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature 3: 93 percent / H2 / 5percent Pd/C / methanol 4: 15.5 percent / dimethylformamide / 1.5 h / 50 °C 5: 317 mg / H2O; ethanol / 72 h / 50 °C 6: 61 percent / DBU / tetrahydrofuran / 2 h / 60 °C 7: 72 percent / H2 / 10percent Pd/C / ethanol 8: 58 percent / TFA / 2 h / Ambient temperature View Scheme