反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 15 - 30 °C 2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere 3.1: sodium methylate / methanol / 1.5 h / 20 °C 4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 85 °C 6.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 33 h / 20 - 100 °C / Inert atmosphere 7.1: hydrogenchloride; hydrogen / palladium on activated charcoal / methanol / 5 h / 20 °C / 3450.35 - 4875.49 Torr 7.2: 120 h View Scheme
