1: (S)-2-[(2'-cyanobiphenyl-4-ylmethyl)amino]-3-methylbutyric acid benzyl ester hydrochloride With sodium hydrogencarbonate in water; toluene T=25°C; 1 h; 2: n-valeryl chloride With N-ethyl-N,N-diisopropylamine in water; toluene T=15 - 25°C; 0.5 - 1 h; 3: With hydrogenchloride in toluene T=0°C; pH=1 - 3; 0.5 h; Product distribution / selectivity;