1: With lithium borohydride in tetrahydrofuran T=65 - 70°C; 10 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=-10 - 0°C; 2 h;

1.1: lithium borohydride / tetrahydrofuran / 10 h / 65 - 70 °C / Inert atmosphere 1.2: 2 h / -10 - 0 °C 2.1: triethylamine / N,N-dimethylaminopyridine 3.1: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 4.1: potassium carbonate; methanol / 25 - 35 °C View Scheme