1: With sodium tetrahydroborate; ethanol T=15 - 60°C; 8 h; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water T=-10 - 0°C; 3 h;

1.1: ethanol; sodium tetrahydroborate / 8 h / 15 - 60 °C / Inert atmosphere 1.2: 3 h / -10 - 0 °C 2.1: triethylamine / N,N-dimethylaminopyridine 3.1: sodium hydrogencarbonate; water; sodium dihydrogen phosphate dihydrate; CAL-B enzyme / 40 - 45 °C / Enzymatic reaction 4.1: potassium carbonate; methanol / 25 - 35 °C View Scheme