4-氯-6,7-二甲氧基喹唑啉合成路线 （共 20 条）
反应条件
thionyl chloride in N,N-dimethyl-formamide 6 h; Heating / reflux;
参考文献
AstraZeneca AB
Patent: US7235559 B1, 2007 ;
US 7235559 B1
反应条件
1: 97 percent / formamide; sodium methoxide / dimethylformamide; methanol / 10 h / Heating 2: 86 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 19.2 percent / 3 h / 165 °C 2: 79.1 percent / SOCl2 / 3 h / Heating View Scheme
参考文献
Synthesis, , # 3 p. 429 - 435
反应条件
1: SOCl2 2: NH4OH 3: NaBH4 / CuSO4 4: Heating 5: POCl2 / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 53, # 6 p. 428 - 439
反应条件
1: NaBH4 / CuSO4 2: Heating 3: POCl2 / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 53, # 6 p. 428 - 439
反应条件
1: Heating 2: POCl2 / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 53, # 6 p. 428 - 439
反应条件
1: NH4OH 2: NaBH4 / CuSO4 3: Heating 4: POCl2 / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 53, # 6 p. 428 - 439
反应条件
1: acetic acid; nitric acid / 0 °C 2: hydrogen; palladium on activated charcoal / methanol 3: 165 - 170 °C 4: trichlorophosphate / toluene View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 293 - 301
反应条件
1: hydrogen; palladium on activated charcoal / methanol 2: 165 - 170 °C 3: trichlorophosphate / toluene View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 293 - 301
反应条件
1: 165 - 170 °C 2: trichlorophosphate / toluene View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 293 - 301
