4-氯-6,7-二甲氧基喹唑啉合成路线 （共 20 条）
反应条件
trichlorophosphate Vilsmeier-Haack Formylation; Cooling with iceMicrowave irradiation;
参考文献
Synthetic Communications, , vol. 43, # 5 p. 719 - 727
反应条件
in isopropyl alcohol 3 h; Reflux;
参考文献
AstraZeneca AB
Patent: EP1218354 B1, 2009 ;
Location in patent: Page/Page column 7-8 ;
反应条件
in acetonitrile T=100°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 5 p. 1371 - 1375
参考文献
Geuns-Meyer, Stephanie D.; Chaffee, Stuart C.; Johnson, Rebecca E.; Kim, Joseph L.; Nunes, Joseph J.; Patel, Vinod F.
Patent: US2007/49592 A1, 2007 ;
Location in patent: Page/Page column 15 ;
反应条件
1: 92 percent / propan-2-ol / 18 h / 25 °C 2: 13 percent / pyridinium hydrochloride / 1 h / 205 °C 3: 42 percent / K2CO3 / dimethylsulfoxide / 4 h / 25 °C View Scheme
参考文献
Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
反应条件
1: 3-bromoaniline hydrochloride / propan-2-ol / Heating 2: Py*HCl / 1 h / 205 °C View Scheme
参考文献
Rewcastle; Denny; Bridges; Zhou; Cody; McMichael; Fry
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3482 - 3487
反应条件
diphenyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; diphenyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H58NO4PPdS; C50H58NO4PPdS; ammonia; sodium t-butanolate in 1,4-dioxane T=50°C; 24 h; Inert atmosphere; Overall yield = 86 percent; Overall yield = 176.6 mg;
参考文献
Cheung, Chi Wai; Surry, David S.; Buchwald, Stephen L.
Organic Letters, 2013 , vol. 15, # 14 p. 3734 - 3737
反应条件
triethylamine in methanol Heating;
参考文献
Trieu, Vuong N.; Liu, Xing-Ping; Chen, Chun-Lin; Uckun, Fatih M.
Journal of Cardiovascular Pharmacology, 2000 , vol. 35, # 2 p. 179 - 188
反应条件
in isopropyl alcohol T=110°C; 3 h;
参考文献
Tran, Anh Thu; Wen, Daying; West, Nicholas P.; Baker, Edward N.; Britton, Warwick J.; Payne, Richard J.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8113 - 8126
反应条件
in isopropyl alcohol T=80°C; 0.533333 h; Microwave irradiation;
参考文献
Marzaro, Giovanni; Guiotto, Adriano; Pastorini, Giovanni; Chilin, Adriana
Tetrahedron, 2010 , vol. 66, # 4 p. 962 - 968
