1-(4-氨基苯甲酰基)-2,3,4,5-四氢苯并[b]氮杂卓-5-酮合成路线 (共 7 条)
反应条件
palladium on activated charcoal; hydrogen in ethanol
参考文献
Organic Process Research and Development, , vol. 7, # 6 p. 883 - 887
反应条件
nickel monoaluminide in N-methyl-acetamide; dichloromethane
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5723606 A1, 1998 ;
反应条件
1: Et3N / CH2Cl2 / 1 h / Ambient temperature 2: H2 / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature View Scheme
参考文献
Tsunoda, Takashi; Yamazaki, Atsuki; Iwamoto, Hidenori; Sakamoto, Shuichi
Organic Process Research and Development, 2003 , vol. 7, # 6 p. 883 - 887
反应条件
1: Et3N / CH2Cl2 / 1 h / Ambient temperature 2: H2 / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature View Scheme
参考文献
Ogawa, Hidenori; Yamashita, Hiroshi; Kondo, Kazumi; Yamamura, Yoshitaka; Miyamoto, Hisashi; Kan, Keizo; Kitano, Kazuyoshi; Tanaka, Michinori; Nakaya, Kenji; Nakamura, Shigeki; Mori, Toyoki; Tominaga, Michiaki; Yabuuchi, Youichi
Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3547 - 3555
反应条件
1: acetic acid; hydrogenchloride / water / 10 h / |Reflux 2: triethylamine / dichloromethane / 2 h / 25 °C 3: hydrogen; palladium on activated charcoal / ethanol View Scheme
参考文献
Tsunoda, Takashi; Yamazaki, Atsuki; Iwamoto, Hidenori; Sakamoto, Shuichi
Organic Process Research and Development, 2003 , vol. 7, # 6 p. 883 - 887
反应条件
triethylamine in dichloromethane
1 h; Ambient temperature;
参考文献
Matsuhisa, Akira; Kikuchi, Kazumi; Sakamoto, Kenichiro; Yatsu, Takeyuki; Tanaka, Akihiro
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 3 p. 329 - 339
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5723606 A1, 1998 ;