7-氯-1,2,3,4-四氢-1-(2-甲基-4-硝基苯甲酰基)-5H-1-苯并氮杂卓-5-酮合成路线 （共 11 条）
反应条件
triethylamine in dichloromethane T=20°C; Acylation; 2 h;
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
1.1: 85 percent / pyridine / 20 °C 2.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 3.1: t-BuOK / toluene / 0.5 h / Heating 3.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating 4.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C 5.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
1.1: 100 percent / K2CO3 / acetone / 0.5 h / Heating 2.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C 3.1: 85 percent / pyridine / 20 °C 4.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 5.1: t-BuOK / toluene / 0.5 h / Heating 5.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating 6.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C 7.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
1: SOCl2 2: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C 2.1: 85 percent / pyridine / 20 °C 3.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 4.1: t-BuOK / toluene / 0.5 h / Heating 4.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating 5.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C 6.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
1.1: 94 percent / K2CO3 / dimethylformamide / 4 h / 120 °C 2.1: t-BuOK / toluene / 0.5 h / Heating 2.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating 3.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C 4.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C 2: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
1.1: t-BuOK / toluene / 0.5 h / Heating 1.2: 60 percent / conc. HCl / acetic acid / 5 h / Heating 2.1: 81 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C 3.1: 32 percent / Et3N / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 8 p. 1743 - 1754
反应条件
hydrogenchloride; tin(ll) chloride in ethanol T=20°C; Reduction;
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
1: 39 percent / SnCl2*2H2O; conc. HCl / ethanol / 20 °C 2: 53 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Dasari Muralidhara; Reddy, Maruthi Janakiram; Krishna, Bandi Vamsi
Patent: US2013/190490 A1, 2013 ;
