莽草酸合成路线 - 魔法化学

莽草酸合成路线（共 91 条）

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反应条件

1: 1.) m-chloroperoxybenzoic acid; 2.) TFAA, 2,6-lutidine / 1.) CH2Cl2, 0 deg C; 2.) CH2Cl2 2: 59 percent / NaClO2, Na2PO4, 2-methyl-2-butene / H2O; 2-methyl-propan-2-ol 3: 53 percent / TFA / H2O View Scheme

参考文献

Tetrahedron Letters, , vol. 39, # 33 p. 6027 - 6028

88400-38-8

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138-59-0莽草酸

反应条件

1: NaBD4 / ethanol / 5 °C 2: acetylation in the usual manner 3: 83 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / 5 °C 4: 1.) and 2.) NaOH / 1.) in methanol-water, 5 deg C, 0.5h; 2.) room temp., 2h View Scheme

参考文献

Tetrahedron Letters, , vol. 24, # 41 p. 4409 - 4412

90927-40-5

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138-59-0莽草酸

反应条件

water; trifluoroacetic acid Ambient temperature; Yield given;

参考文献

Tetrahedron Letters, , vol. 35, # 30 p. 5505 - 5508

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反应条件

E. coli SP1.1; pKD12112 12 h; var. time; Product distribution;

参考文献

Journal of the American Chemical Society, , vol. 121, # 7 p. 1603 - 1604

146830-40-2

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138-59-0莽草酸

反应条件

1: 97 percent / iPr2EtN / CH2Cl2 2: 79 percent / Zn, AcOH / ethanol 3: 86 percent / NaHCO3 / diphenyl ether / 0.5 h / 260 °C 4: Et3N, DMAP / CH2Cl2 / 0 °C 5: Bu3SnH, AIBN / benzene / 80 °C 6: 30percent H2O2, KHCO3 / methanol; tetrahydrofuran / Heating 7: 100 percent / imidazole / dimethylformamide 8: iPrEtN, DMAP / CH2Cl2 9: TBAF / tetrahydrofuran 10: SO3*Py, Et3N / dimethylsulfoxide 11: NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O 12: CH2Cl2 13: 98 percent / AcCl / methanol 14: 96 percent / aq. 1 M NaOH / tetrahydrofuran; H2O View Scheme

参考文献

Chemistry Letters, , # 11 p. 987 - 988

146830-39-9

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138-59-0莽草酸

反应条件

1: 86 percent / OsO4, N-methylmorpholine N-oxide / tetrahydrofuran; H2O 2: 97 percent / iPr2EtN / CH2Cl2 3: 79 percent / Zn, AcOH / ethanol 4: 86 percent / NaHCO3 / diphenyl ether / 0.5 h / 260 °C 5: Et3N, DMAP / CH2Cl2 / 0 °C 6: Bu3SnH, AIBN / benzene / 80 °C 7: 30percent H2O2, KHCO3 / methanol; tetrahydrofuran / Heating 8: 100 percent / imidazole / dimethylformamide 9: iPrEtN, DMAP / CH2Cl2 10: TBAF / tetrahydrofuran 11: SO3*Py, Et3N / dimethylsulfoxide 12: NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O 13: CH2Cl2 14: 98 percent / AcCl / methanol 15: 96 percent / aq. 1 M NaOH / tetrahydrofuran; H2O View Scheme

参考文献

Chemistry Letters, , # 11 p. 987 - 988

146830-37-7

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138-59-0莽草酸

反应条件

1: K2CO3 / methanol 2: NBS / CH2Cl2 3: 86 percent / OsO4, N-methylmorpholine N-oxide / tetrahydrofuran; H2O 4: 97 percent / iPr2EtN / CH2Cl2 5: 79 percent / Zn, AcOH / ethanol 6: 86 percent / NaHCO3 / diphenyl ether / 0.5 h / 260 °C 7: Et3N, DMAP / CH2Cl2 / 0 °C 8: Bu3SnH, AIBN / benzene / 80 °C 9: 30percent H2O2, KHCO3 / methanol; tetrahydrofuran / Heating 10: 100 percent / imidazole / dimethylformamide 11: iPrEtN, DMAP / CH2Cl2 12: TBAF / tetrahydrofuran 13: SO3*Py, Et3N / dimethylsulfoxide 14: NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O 15: CH2Cl2 16: 98 percent / AcCl / methanol 17: 96 percent / aq. 1 M NaOH / tetrahydrofuran; H2O View Scheme

参考文献

Chemistry Letters, , # 11 p. 987 - 988

146830-41-3

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138-59-0莽草酸

反应条件

1: 79 percent / Zn, AcOH / ethanol 2: 86 percent / NaHCO3 / diphenyl ether / 0.5 h / 260 °C 3: Et3N, DMAP / CH2Cl2 / 0 °C 4: Bu3SnH, AIBN / benzene / 80 °C 5: 30percent H2O2, KHCO3 / methanol; tetrahydrofuran / Heating 6: 100 percent / imidazole / dimethylformamide 7: iPrEtN, DMAP / CH2Cl2 8: TBAF / tetrahydrofuran 9: SO3*Py, Et3N / dimethylsulfoxide 10: NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O 11: CH2Cl2 12: 98 percent / AcCl / methanol 13: 96 percent / aq. 1 M NaOH / tetrahydrofuran; H2O View Scheme

参考文献

Chemistry Letters, , # 11 p. 987 - 988

146830-42-4

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138-59-0莽草酸

反应条件

1: 86 percent / NaHCO3 / diphenyl ether / 0.5 h / 260 °C 2: Et3N, DMAP / CH2Cl2 / 0 °C 3: Bu3SnH, AIBN / benzene / 80 °C 4: 30percent H2O2, KHCO3 / methanol; tetrahydrofuran / Heating 5: 100 percent / imidazole / dimethylformamide 6: iPrEtN, DMAP / CH2Cl2 7: TBAF / tetrahydrofuran 8: SO3*Py, Et3N / dimethylsulfoxide 9: NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O 10: CH2Cl2 11: 98 percent / AcCl / methanol 12: 96 percent / aq. 1 M NaOH / tetrahydrofuran; H2O View Scheme

参考文献

Chemistry Letters, , # 11 p. 987 - 988

146830-38-8

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138-59-0莽草酸

反应条件

1: NBS / CH2Cl2 2: 86 percent / OsO4, N-methylmorpholine N-oxide / tetrahydrofuran; H2O 3: 97 percent / iPr2EtN / CH2Cl2 4: 79 percent / Zn, AcOH / ethanol 5: 86 percent / NaHCO3 / diphenyl ether / 0.5 h / 260 °C 6: Et3N, DMAP / CH2Cl2 / 0 °C 7: Bu3SnH, AIBN / benzene / 80 °C 8: 30percent H2O2, KHCO3 / methanol; tetrahydrofuran / Heating 9: 100 percent / imidazole / dimethylformamide 10: iPrEtN, DMAP / CH2Cl2 11: TBAF / tetrahydrofuran 12: SO3*Py, Et3N / dimethylsulfoxide 13: NaClO2, NaH2PO4*2H2O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O 14: CH2Cl2 15: 98 percent / AcCl / methanol 16: 96 percent / aq. 1 M NaOH / tetrahydrofuran; H2O View Scheme

参考文献

Chemistry Letters, , # 11 p. 987 - 988

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