4-氧代-1,4-二氢-2,6-吡啶二甲酸合成路线 （共 41 条）
反应条件
1: phosphorus pentabromide / 1.75 h / 90 °C 2: 6.56 g / CHCl3 / ice cooling 3: 91 percent / aq. LiOH / tetrahydrofuran / 2.75 h 4: 92 percent / oxalyl chloride; DMF / CH2Cl2 / 20 h / Heating View Scheme
参考文献
Pryor, Kent E.; Shipps Jr., Gerald W.; Skyler, David A.; Rebek Jr., Julius
Tetrahedron, 1998 , vol. 54, # 16 p. 4107 - 4124
反应条件
1.1: PCl5 / CCl4 / 120 °C 1.2: 54 percent / Heating 2.1: aq. NaOH / 80 °C 3.1: 43 percent / aq. H2SO4 / 120 °C 4.1: 83 percent / methanol / Heating 5.1: 91 percent / NaBH4 / CH2Cl2; methanol / 5.5 h / 0 - 20 °C 6.1: 88 percent / MnO2 / CH2Cl2 / 20 °C View Scheme
参考文献
Bhattacharya, Santanu; Snehalatha, Karnam; George, Shaji K.
Journal of Organic Chemistry, 1998 , vol. 63, # 1 p. 27 - 35
反应条件
phosphoric acid T=200°C; 4 h;
参考文献
Carina, Riccardo F.; Williams, Alan F.; Piguet, Claude
Helvetica Chimica Acta, 1998 , vol. 81, # 3 p. 548 - 557
反应条件
1: 71 percent / K2CO3 / acetone / 72 h / Heating 2: 93 percent / NH3 / methanol / 3 h / 20 °C View Scheme
参考文献
Lou, Nan; Wang, Yangyang; Li, Haixia; Sokolov, Alexei P.; Xiong, Huiming
Polymer (United Kingdom), 2012 , vol. 53, # 20 p. 4455 - 4460
反应条件
1: H2SO4 / toluene / 20 h / Heating 2: 18.4 g / KOH / ethanol / Heating View Scheme
参考文献
Berl, Volker; Huc, Ivan; Khoury, Richard G.; Lehn, Jean-Marie
Chemistry - A European Journal, 2001 , vol. 7, # 13 p. 2798 - 2809
反应条件
bromine; phosphorus tribromide in ethanol
参考文献
Pryor, Kent E.; Shipps Jr., Gerald W.; Skyler, David A.; Rebek Jr., Julius
Tetrahedron, 1998 , vol. 54, # 16 p. 4107 - 4124
反应条件
phosphorus pentabromide in chloroform T=90°C; 3 h; Inert atmosphere;
参考文献
Broadley, Kenneth J.; Davies, Robin H.; Escargueil, Christine; Lee, Alan T.L.; Penson, Peter; Thomas, Eric J.
Collection of Czechoslovak Chemical Communications, 2011 , vol. 76, # 7 p. 781 - 801
反应条件
1: sulfuric acid / 20 °C / Reflux 2: phosphorus tribromide / chloroform / 3 h / 90 °C View Scheme
参考文献
Tong, Lianpeng; Goethelid, Mats; Sun, Licheng
Chemical Communications, 2012 , vol. 48, # 80 p. 10025 - 10027
反应条件
1: 86 percent / SOCl2 / dimethylformamide / 2 h / Heating 2: 68 percent / diethyl ether / 1 h / 0 °C 3: 99 percent / aq. HI / CH2Cl2 / 48 h View Scheme
参考文献
Dumont, Arnaud; Jacques, Vincent; Desreux, Jean F.
Tetrahedron, 2000 , vol. 56, # 14 p. 2043 - 2052
反应条件
1: Br2; PBr3 / ethanol 2: NaBH4 View Scheme
参考文献
Yang, Yin; Li, Qing-Feng; Cao, Chan; Huang, Feng; Su, Xun-Cheng
Chemistry - A European Journal, 2013 , vol. 19, # 3 p. 1097 - 1103
