1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / |Inert atmosphere 2.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / |Inert atmosphere 2.2: 0.08 h 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 4.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0 - 20&deg;C;&nbsp;4&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / ethyl acetate / 8 h / 0 - 20 &deg;C<br />1.2: 0.08 h<br />2.1: triethylamine / dichloromethane / 4 h / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile<br />2: triethylamine / dichloromethane<br />3: dicyclohexyl-carbodiimide / ethyl acetate<br />4: sodium tetrahydroborate / tetrahydrofuran<br />5: pyridine<br /> <br /> &nbsp;