反应条件
1.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 0 °C 1.2: 3 h / -15 °C 2.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 0.5 h / 60 °C 2.2: 8 h / 60 °C 3.1: hydrogenchloride; formaldehyd / water; tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
PHARMATHEN S.A.; KOFTIS, Theocharis V.; ANDREOU, Thanos; ZITROU, Asteria
Patent: WO2012/76030 A1, 2012 ;
