2,4-双(甲氧基甲氧基)-1-甲基苯合成路线 (共 1 条)
反应条件
1: 1,3-dihydroxy-4-methylbenzene With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.25 h; 2: chloromethyl methyl ether in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 1 h;
参考文献
AUTIFONY THERAPEUTICS LIMITED; Alvaro, Giuseppe; Dambruoso, Paolo; Tommasi, Simona; Decor, Anne; Large, Charles
Patent: US2013/267510 A1, 2013 ;
Location in patent: Paragraph 0936-0938 ;