(R)-1-Boc-3-羟甲基吡咯烷合成路线 （共 13 条）
反应条件
1: With borane-THF in tetrahydrofuran T=20 - 55°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; water T=0 - 20°C;
参考文献
WO2011/150198 A1, ;
Page/Page column 151 ;
WO 2011/150198 A1
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
US2013/184313 A1, ;
Paragraph 1653; 1654 ;
反应条件
hydrogen; palladium hydroxide - carbon in methanol; water P=2068.59 Torr; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 4 p. 677 - 690
反应条件
[((R,R)-3,5-t-Bu-salen)Co(III)(OTf)] in tert-butyl methyl ether T=40°C; 72 h; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 131, p. 2786 - 2787
反应条件
triethylamine in dichloromethane
反应条件
potassium hydroxide in methanol T=20°C; 18 h;
参考文献
Synlett, , # 6 p. 921 - 924
反应条件
Resolution of racemate;
参考文献
WO2004/108677 A1, ;
Page 138 ;
WO 2004/108677 A1
反应条件
borane-THF in tetrahydrofuran 1.) 0 deg C, 2 h, 2.) room temperature, overnight;
参考文献
Journal of Organic Chemistry, , vol. 62, # 13 p. 4285 - 4292
反应条件
1: hydrogen, Rh(acac)(CO)2, (R)-2-(diphenylphosphino)-1,1'-binaphthalen-2'-yl (S)-3,3'-dimethyl-1,1'-binaphthalene-2,2'-diyl phosphite / benzene / 72 h / 60 °C / 76000 Torr 2: borane-THF / tetrahydrofuran / 1.) 0 deg C, 2 h, 2.) room temperature, overnight View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 13 p. 4285 - 4292
