2,4-二甲氧基苯基溴化镁合成路线 （共 9 条）
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 19, p. 77 - 90
反应条件
in tetrahydrofuran react. under N2; THF cooled to -60°C, addn. of borate and Grignard reagent in THF simultaneously (equimolar amts. over whole period of react.), then stirred for 30 min at -60°C, warmed to room temp., stirred for 30 min;; treated with water, extd. with Et2O, organic layers extd. with 1M aq. NaOH, aq. layers acidified with 2M aq. HCl, extd. with CH2Cl2, organic layers dried (MgSO4), filtered, concentrated, recrystd. from ethanol/water;;
参考文献
Banwell, Martin G.; Cameron, Jennifer M.; Collis, Maree P.; Crisp, Geoffrey T.; Gable, Robert W.; et al.
Australian Journal of Chemistry, 1991 , vol. 44, p. 705 - 728
反应条件
methylmagnesium bromide; NiCl2((PPh3)P)2 in diethyl ether; benzene
Heating;
参考文献
Wenkert, Ernest; Fernandes, Joao Battista; Michelotti, Enrique L.; Swindell, Charles S.
Synthesis, 1983 , # 9 p. 701 - 703
反应条件
methylmagnesium bromide; NiCl2((PPh3)P)2 in diethyl ether; benzene
Heating;
参考文献
Wenkert, Ernest; Fernandes, Joao Battista; Michelotti, Enrique L.; Swindell, Charles S.
Synthesis, 1983 , # 9 p. 701 - 703
反应条件
in tetrahydrofuran
T=0°C; 2 h;
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
1: tetrahydrofuran / 2 h / 0 °C
2: pyridine; hydrazine / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
1.1: tetrahydrofuran / 2 h / 0 °C
2.1: pyridine; hydrazine / 1 h / 100 °C / Microwave irradiation
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 - 60 °C
3.2: 4 h / 60 °C
View Scheme
参考文献
Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H.
Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
反应条件
phosphorus trichoride in tetrahydrofuran
T=-78 - 50°C;
参考文献
DOW GLOBAL TECHNOLOGIES INC.; BRIGGS, John; PATTON, Jasson; VERMAIRE-LOUW, Sonet; MARGL, Peter; HAGEN, Henk; BEIGZADEH, Daryoosh
Patent: WO2010/19360 A2, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
1: CH2Cl2; diethyl ether / 1 h / 20 °C
2: HCl; methanol / diethyl ether / 6.5 h / 20 °C
View Scheme
参考文献
Kitamura, Mitsuru; Suga, Takahiro; Chiba, Shunsuke; Narasaka, Koichi
Organic Letters, 2004 , vol. 6, # 24 p. 4619 - 4621
