7-甲氧基-1-萘乙酰胺合成路线 （共 15 条）
反应条件
ammonia in toluene T=0 - 5°C; pH=10 - 11;
参考文献
ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat, Raman; PANCHASARA, Dineshkumar, Ramabhai; PATEL, Ilesh; PRAJAPATI, Bhavesh; PATEL, Ketan; PATWA, Mitul; SHAH, Ankit
Patent: WO2014/1939 A1, 2014 ;
Location in patent: Page/Page column 16 ;
反应条件
1: SOCl2 / CHCl3 / 2 h / Heating 2: conc. aq. NH3 / diethyl ether / 0.5 h View Scheme
参考文献
Archiv der Pharmazie, , vol. 326, # 2 p. 119 - 120
反应条件
1.1: zinc / iodine / toluene / Reflux 1.2: Reflux 1.3: 3 h / Reflux 2.1: sulfur / ethyl acetate / 10 h / 215 °C 3.1: sodium hydroxide; water / ethanol / 3 h / 20 °C 4.1: thionyl chloride / dichloromethane / 2 h / Reflux 5.1: ammonia / ethyl acetate; water / Cooling with ice View Scheme
反应条件
1: sodium hydroxide; water / ethanol / 3 h / 20 °C 2: thionyl chloride / dichloromethane / 2 h / Reflux 3: ammonia / ethyl acetate; water / Cooling with ice View Scheme
反应条件
1: sulfur / ethyl acetate / 10 h / 215 °C 2: sodium hydroxide; water / ethanol / 3 h / 20 °C 3: thionyl chloride / dichloromethane / 2 h / Reflux 4: ammonia / ethyl acetate; water / Cooling with ice View Scheme
反应条件
1: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 3: ammonia / toluene / 0 - 5 °C / pH 10 - 11 View Scheme
反应条件
1: potassium hydroxide / tert-butyl alcohol / 2 h / 85 - 90 °C 2: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 4: ammonia / toluene / 0 - 5 °C / pH 10 - 11 View Scheme
反应条件
1: AlH4 / diethyl ether 2: K2CO3 / H2O; CHCl3 / 0 °C View Scheme
参考文献
Tianjin Taipu Pharmaceutical Science and Technology Development Co., Ltd.
Patent: EP2474522 A1, 2012 ;
反应条件
dimethylsulfide borane complex in toluene T=80 - 85°C; Product distribution / selectivity;
参考文献
Tianjin Taipu Pharmaceutical Science and Technology Development Co., Ltd.
Patent: EP2474522 A1, 2012 ;
反应条件
tetrahydridoaluminate(1-) in diethyl ether
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 8 p. 1484 - 1486
