7-甲氧基-1-萘基乙腈合成路线 （共 30 条）
反应条件
1: 90.7 percent / DDQ / CH2Cl2 / 20 °C 2: 88.2 percent / TsOH*H2O / benzene / 1 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 31, # 4 p. 621 - 629
反应条件
1: sodium hydroxide; water / ethanol / 3 h / 20 °C 2: thionyl chloride / dichloromethane / 2 h / Reflux 3: ammonia / ethyl acetate; water / Cooling with ice 4: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
反应条件
1: sulfur / ethyl acetate / 10 h / 215 °C 2: sodium hydroxide; water / ethanol / 3 h / 20 °C 3: thionyl chloride / dichloromethane / 2 h / Reflux 4: ammonia / ethyl acetate; water / Cooling with ice 5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 1.5 h / |Reflux; |Microwave irradiation 2: dimethyl sulfoxide / 3 h / 140 - 145 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 45, # 4 p. 328 - 331
反应条件
1.1: aluminum isopropoxide / isopropyl alcohol / 20 °C / |Reflux 1.2: 1 h / |Dean-Stark; |Reflux 2.1: chloranil / toluene / 2.5 h / 80 °C View Scheme
反应条件
1.1: ethyl acetate / 0.25 h / |Reflux; |Inert atmosphere 1.2: |Reflux 2.1: chlorobenzene / 0.25 h / |Reflux; |Inert atmosphere 2.2: |Reflux 3.1: aluminum isopropoxide / isopropyl alcohol / 20 °C / |Reflux 3.2: 1 h / |Dean-Stark; |Reflux 4.1: chloranil / toluene / 2.5 h / 80 °C View Scheme
反应条件
1.1: chlorobenzene / 0.25 h / |Reflux; |Inert atmosphere 1.2: |Reflux 2.1: aluminum isopropoxide / isopropyl alcohol / 20 °C / |Reflux 2.2: 1 h / |Dean-Stark; |Reflux 3.1: chloranil / toluene / 2.5 h / 80 °C View Scheme
反应条件
1: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 3: ammonia / toluene / 0 - 5 °C / pH 10 - 11 4: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C View Scheme
反应条件
1: potassium hydroxide / tert-butyl alcohol / 2 h / 85 - 90 °C 2: palladium on activated charcoal; sodium carbonate; acrylic acid / water / 100 - 105 °C 3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 35 - 40 °C 4: ammonia / toluene / 0 - 5 °C / pH 10 - 11 5: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 85 °C View Scheme
反应条件
1: 4-hydroxy-benzoic acid; benzylamine / toluene / 6 h / 108 - 110 °C 2: palladium on activated charcoal / toluene / 30 h / |Reflux 3: potassium carbonate / acetone / 3 h / |Reflux View Scheme
