1.1: sodium hydroxide; water / ethanol / 72 h / Reflux 1.2: pH 1 - 1.2 1.3: 35 h / 155 °C 2.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 2.2: pH 1 - 1.2 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C 3.2: 5 °C 4.1: triphenylphosphine; N-bromosuccinmide / dichloromethane / 4 h / 5 - 10 °C View Scheme

1.1: sodium hydroxide; water / ethanol / 72 h / Reflux 1.2: pH 1 - 1.2 1.3: 35 h / 155 °C 2.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 2.2: pH 1 - 1.2 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C 3.2: 5 °C View Scheme

1.1: sodium hydroxide; water / ethanol / 72 h / Reflux 1.2: pH 1 - 1.2 1.3: 35 h / 155 °C 2.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 2.2: pH 1 - 1.2 View Scheme