trimethylsilyl bromide in acetonitrile Ambient temperature;

1: 70 percent / potassium carbonate, DABCO / H2O / 2 h / Heating 2: 72 percent / Me3SiBr / acetonitrile / Ambient temperature View Scheme

1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature; 2) pyridine, room temperature 2: sodium hydride / dimethylformamide / 24 h / Ambient temperature 3: methanol / Ambient temperature 4: bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme

1: 91 percent / aq. HCl / 1 h / Heating 2: 1.) chlorotrimethylsilane / 1) pyridine, room temperature; 2) pyridine, room temperature 3: sodium hydride / dimethylformamide / 24 h / Ambient temperature 4: methanol / Ambient temperature 5: bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme

1: sodium hydride / dimethylformamide / 24 h / Ambient temperature 2: methanol / Ambient temperature 3: bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme

1: methanol / Ambient temperature 2: bromotrimethylsilane / acetonitrile / Ambient temperature View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C 2: lithium tert-butylate / 1-methyl-pyrrolidin-2-one / 5 h / 70 °C 3: sodium bromide; chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one / 5 h / 0 - 75 °C 4: hydrogenchloride; water / 1-methyl-pyrrolidin-2-one; ethanol / 3 h / 55 °C View Scheme

1: lithium tert-butylate / 1-methyl-pyrrolidin-2-one / 5 h / 70 °C 2: sodium bromide; chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one / 5 h / 0 - 75 °C 3: hydrogenchloride; water / 1-methyl-pyrrolidin-2-one; ethanol / 3 h / 55 °C View Scheme

1: sodium bromide; chloro-trimethyl-silane / 1-methyl-pyrrolidin-2-one / 5 h / 0 - 75 °C 2: hydrogenchloride; water / 1-methyl-pyrrolidin-2-one; ethanol / 3 h / 55 °C View Scheme